Accession Number : ADA293968

Title :   Filtering, Smoothing, and Extrapolations in Dose-Response Experiments: With Application to Data on Respiratory Tumor in Rats.

Corporate Author : GEORGE WASHINGTON UNIV WASHINGTON DC

Personal Author(s) : Sinpurwalla, Nozer D. ; Chen, Jingxian

PDF Url : ADA293968

Report Date : 1990

Pagination or Media Count : 12

Abstract : A method for inference and extrapolations in certain dose- response. damage-assessments and accelerated life-testing studies as been proposed by Meinhold and Singpurwalla in 1986. The method is based on a use of the Kalman-filter algorithm and involves the double lognormal as the distributional assumption. In this paper we discuss issues pertaining to a practical implementation of this methodology. This involves some insights based on a simulation study about the specification of prior parameters and an application of the proposed methodology to some published data on doses of bischloromethyl ether administered to rats.

Descriptors :   *NEOPLASMS, *RESPIRATORY SYSTEM, ALGORITHMS, SIMULATION, RATS, DAMAGE ASSESSMENT, KALMAN FILTERING, DOSAGE, RESPONSE(BIOLOGY), LIFE TESTS, ACCELERATED TESTING, BIOASSAY, EXTRAPOLATION.

Subject Categories : Pharmacology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE