Accession Number : ADA294065

Title :   Measurement and Regulation of Central Noradrenergic Receptors.

Descriptive Note : Final rept. 1 Dec 91-30 Nov 94,

Corporate Author : NEW YORK UNIV MEDICAL CENTER NY

Personal Author(s) : Stone, Eric A. ; Mncln, Sanil J. ; Zhang, Yi

PDF Url : ADA294065

Report Date : 30 NOV 1994

Pagination or Media Count : 5

Abstract : Progress was made in a number of areas related to the role of the central noradrenergic system in the behavioral effects of stress. First we established that norepinephrine mediates the persistent anxiety after stress as other have found in various learning paradigms thus linking studies of stress to studies of learned anxiety. Second we showed that a likely factor in this effect is the stimulation of the gene, c-fos, which we found to be stimulated throughout the brain by the noradrenergic system during stress. Third we discovered a new phenomenon caused by stress involving a transient reduction in arousal which causes animals to lose caution in dangerous situations and may be related to temporary desensitization of the brain beta-1 adrenoceptor. Fourth we found that repeated stress in mice causes a progressive decline in nocturnal activity and feeding thus establishing a new animal model of depression which will facilitate studies of the role of the noradrenergic system in behavioral depression.

Descriptors :   *NERVE CELLS, *NOREPINEPHRINE, *CEREBRAL CORTEX, *NERVE TRANSMISSION, STRESSES, TRANSIENTS, STIMULATION(GENERAL), BRAIN, MODELS, REDUCTION, GENES, ANIMALS, NIGHT, BEHAVIOR, MICE, LEARNING, INFORMATION PROCESSING, ANATOMICAL MODELS, ANXIETY.

Subject Categories : Anatomy and Physiology
      Psychology

Distribution Statement : APPROVED FOR PUBLIC RELEASE