Accession Number : ADA294497

Title :   Host Factors Contributing to Disability Following Sulfur Mustard Exposure.

Descriptive Note : Final rept. 30 Mar 90-31 Dec 94,

Corporate Author : JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF HYGIENE AND PUBLIC HEALTH

Personal Author(s) : Dannenberg, Arthur M., Jr

PDF Url : ADA294497

Report Date : 31 JAN 1995

Pagination or Media Count : 78

Abstract : Cytokines in SM lesions. We demonstrated the mRNAs of four major cytokines in developing and healing rabbit SM lesions: Interleukin 1 (beta), (IL-1 (beta)), neutrophil attractant/activation protein-i (NAP-1 or IL-8), monocyte chemoattractant (activating) protein 1 (MCP-1), and the chemokine GRO (a growth factor and chemoattractant for granulocytes). The macrophages and activated fibroblasts in the lesions contained the mRNA of all four cytokines, with the highest amounts in the peak lesions and decreased amounts during healing. Granul ocytes contained the mRNA of IL-1 (beta) and NAP-1. In the epithel ial cells of hair follicles, GRO mRNA was up-regulated as early as 1 hour after the the application of sulfur mustard and remained high during the healing process. In SM lesions (but not in normal skin), surface epithelial cells and/or hair follicle epithelial cells contained the mRNA of NAP-1, MCP-1 and GRO.

Descriptors :   *HORMONES, *MUSTARD AGENTS, *SULFUR, *CELLS(BIOLOGY), *HOSTS(BIOLOGY), PEAK VALUES, ACTIVATION, EPITHELIUM, GROWTH(GENERAL), PROTEINS, SURFACES, FIBROBLASTS, GRANULOCYTES, MACROPHAGES, LESIONS, HEALING, RABBITS, HAIR.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE