Accession Number : ADA294504

Title :   Inhibition of Rabbit Sperm Cell Hyperactivated Motility by Metallic Ions in Toxicological Testing.

Descriptive Note : Final rept. Nov 90-Aug 92,

Corporate Author : EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUND MD

Personal Author(s) : Young, Ronald J. ; Heitkamp, Dale H.

PDF Url : ADA294504

Report Date : MAR 1995

Pagination or Media Count : 20

Abstract : Rabbit sperm cells developed hyperactivated motility when incubated in medium N. Hyperactivated but not normal progressive motility was inhibited by lead and cadmium, two metals implicated in fertility dysfunction. A metal of military interest, Cr+6, had a similar outcome on rabbit sperm, suggesting that it may also have the same property as cadmium and lead. Two metals, zinc and mercury, without fertility effects did not suppress hyperactivated motility. The rabbit sperm-medium M-hyperactivated motility system may have a role in the in vitro assessment of the antifertility effects of chemicals.

Descriptors :   *TOXICOLOGY, *REPRODUCTION(PHYSIOLOGY), *SPERMATOGENESIS, METALS, MOBILITY, CHEMICALS, IN VITRO ANALYSIS, MERCURY, ZINC, CADMIUM, INHIBITION, DYSFUNCTION, FERTILITY.

Subject Categories : Biology
      Medicine and Medical Research
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE