Accession Number : ADA294542

Title :   Early Detection of Breast Cancer and Recurrence Following Therapy with Magnetic Resonance Imaging and Spectroscopy.

Descriptive Note : Annual rept. 15 Mar 94-14 Mar 95,

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA

Personal Author(s) : Lenkinski, Robert E. ; Solin, Lawrence

PDF Url : ADA294542

Report Date : 15 APR 1995

Pagination or Media Count : 25

Abstract : The major hypothesis of this project is that use of a combination of Magnetic Resonance Imaging (MRI), MRI with contrast, magnetization transfer contrast and proton Magnetic Resonance spectroscopy (MRS) will lead to improved detection and characterization of breast cancer. At present mammography detects lesions which have about an 80% false positive rate for malignancy. There are strong preliminary indications that the combination of MRI with dynamic contrast uptake studies can both detect lesions and provide improved characterization over mammography. The addition of the metabolically based MRS parameters into an approach based on multivariate classification should improve the characterization even further. Technical progress has been made in three areas: the development of a breast array for bilateral imaging of the breast, the development of B1 mapping methods and improvements in the use of multicoil MRS. In the second year of this study. additionai measurements have been obtained on: 25 patients undergoing breast-conserving surgery and definitive breast irradiation for treatment of early stage breast cancer; 18 patients undergoing breast biopsy for suspicious breast abnormalities, but without a confirmed diagnosis of malignancy; and 2 patient with locally advanced breast cancer. (AN)

Descriptors :   *METABOLISM, *CANCER, *MAMMARY GLANDS, IMAGE PROCESSING, CONTRAST, DETECTION, SPECTROSCOPY, MULTIVARIATE ANALYSIS, COMPARISON, CLINICAL MEDICINE, OPTICAL IMAGES, HIGH RESOLUTION, MAGNETIC RESONANCE, DIAGNOSIS(MEDICINE), DATA ACQUISITION, HYPOTHESES, IRRADIATION, RESPONSE(BIOLOGY), MEDICAL RESEARCH, MAGNETIZATION, SURGERY, MEDICAL EQUIPMENT, COMPUTERIZED TOMOGRAPHY, ABNORMALITIES, CHEMOTHERAPY, LESIONS, BIOPSY, RADIOTHERAPY.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE