Accession Number : ADA296108

Title :   Vaccination Against Cholesterol: Immunologic Modulation of Diet-Induced Hypercholesterolemia and Atherosclerosis in Rabbits.

Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Personal Author(s) : Alving, Carl R. ; Swartz, Glenn M., Jr. ; Wasssef, Nabila M. ; Herderick, Edward E. ; Virmani, Renu

PDF Url : ADA296108

Report Date : 1995

Pagination or Media Count : 4

Abstract : Immunization of rabbits with a protein-ftee formulation consisting of liposomes containing 71% cholesterol and lipid A as an adjuvant induced antibodies that recognized highly purified nonoxidized crystalline cholesterol and rabbit VLD/IDl by ELISA. In rabbits that were fed an atherogenic diet containing O.5%-l.O% cholesterol, a marked diminution of hypercholesterolemia (as much as 979 mg/dl lower) was observed in the immunized animals when compared to nonimmunized controls. Analysis of aortic fatty streaks by automated morphometric probability-of-occurrence mapping of audanophilia showed significantly diminished lesions in vaccines in most areas of the aorta.

Descriptors :   *CHOLESTEROL, *IMMUNOLOGY, *DIET, *VACCINES, *RABBITS, ENZYMES, LIPOSOMES, ANTIBODIES, ANIMALS, MODULATION, IMMUNOASSAY, IMMUNIZATION, AORTA, ATHEROSCLEROSIS, HYPERCHOLESTEROLEMIA.

Subject Categories : Medicine and Medical Research
      Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE