Accession Number : ADA296358

Title :   Insulin-Like Growth Factor II as a Prognostic Indicator in Breast Cancer.

Descriptive Note : Annual rept.,

Corporate Author : GEORGETOWN UNIV WASHINGTON DC

Personal Author(s) : Cullen, Kevin J.

PDF Url : ADA296358

Report Date : 14 JAN 1995

Pagination or Media Count : 17

Abstract : Insulin-like growth factor II is a potent mitogen for breast tumor epithelium. The purpose of this study is to analyze IGF-II expression in a series of breast tumor biopsy specimens and determine whether IGF-II expression relates to clinical indicators and outcome. We have processed over 300 cases by in situ hybridization and immunohistochemistry. Of 240 cases scored so far, IGF-II protein expression was absent in 16%, low in 23%, moderate in 43% and high in 18%. These data correlate well with the data obtained by in situ hybridization. Preliminary correlation with clinical parameters and outcome shows that IGF-II expression may be associated with poor prognosis in patients who are negative for estrogen and progesterone receptor.

Descriptors :   *CLINICAL MEDICINE, *CANCER, *MAMMARY GLANDS, *INSULIN, PREDICTIONS, PARAMETERS, NEOPLASMS, CHEMISTRY, IMMUNOLOGY, INDICATORS, SENSE ORGANS, HISTOLOGY, BIOPSY, HYBRIDIZATION, PROGESTERONE, ESTROGENS.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE