Accession Number : ADA296762

Title :   Carboxyalkylated Crosslinked Hemoglobin as a Potential Blood Substitute.

Descriptive Note : Annual rept. 15 Jun 94-14 Jun 95,

Corporate Author : ROCKEFELLER UNIV NEW YORK

Personal Author(s) : Manning, James M.

PDF Url : ADA296762

Report Date : JUL 1995

Pagination or Media Count : 34

Abstract : Our research supported by this contract has been directed along 3 main lines: (1) analysis of crosslinked hemoglobin samples (64,000 MW) from the U.S. Army Medical Research Detachment headed by Col. John Hess. This has been achieved by various protein separation methods under both native and denaturing conditions in order to monitor the product of the pilot plant. (2) studies on the preparation of higher molecular weight crosslinked hemoglobins (128,000 MW). Various bifunctional agents are being evaluated and (3) studies on recombinant hemoglobins to understand the molecular basis for the low oxygen affinity of certain hemoglobins as a basis for future blood substitute research.

Descriptors :   *HEMOGLOBIN, *BLOOD SUBSTITUTES, MONITORING, PROTEINS, CROSSLINKING(CHEMISTRY), SAMPLING, SEPARATION, PILOT PLANTS.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE