Accession Number : ADA296763
Title : The Efficacy of Cyanoacrylates in the Primary Closure of Conjunctival-Schleral Lacerations.
Descriptive Note : Final rept. 18 Jun 90-15 Feb 94,
Corporate Author : WALTER REED ARMY MEDICAL CENTER WASHINGTON DC
Personal Author(s) : Cavallaro, Brian ; Hollifield, Rodney ; Ward, Thomas ; Wertz, Fleming
PDF Url : ADA296763
Report Date : 15 FEB 1995
Pagination or Media Count : 21
Abstract : We designed a study to evaluate the efficacy of cyanoacrylate adhesive (CA) in the temporary closure of scleral lacerations. Ocular injuries are expected to comprise up to 10% of total casualties on the modern battlefield and would overwhelm the limited medical facilities near front lines. An expedient method of stabilizing open eyes is needed. A 6 mm laceration was created 3 mm posterior to the limbus in albino rabbits. The animals were randomized into three groups: standard closure with sutures (13), closure with CA (28), or untreated (21). The animals were euthanized at 2 days, 1, 2, 4, and 8 weeks. On histopathologic examination, a fibrous bridge was noted in all animals by 2 weeks. Prior to fibrous bridge formation, intraocular pressures (lOP's) and dark- adapted electroretinogram (ERG) a- - and b-wave amplitudes were lower in open eyes compared to those in which wounds were surgically closed using CA or- suture.- - Flare was increased in open eyes. The clinical course- of the CA-group'compared favorably with eyes closed by -the standard suture technique. - This study supports the efficacy of - using cyanoacrylate adhesive as a temporary, expedient method of closing scleral lacerations.
Descriptors : *CYANIDES, *CONJUNCTIVITIS, *CYANOGEN, FIBERS, CLOSURES, BATTLEFIELDS, PRESSURE, CASUALTIES, SUPPORTS, ANIMALS, WOUNDS AND INJURIES, EYE, PATHOLOGY, ACRYLATES, ADHESIVES, BRIDGES, HISTOLOGY, RABBITS, ALBINISM, ELECTRORETINOGRAPHY, SUTURES.
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE