Accession Number : ADA296766

Title :   The Molecular Heterogeneity of Salivary Platelet-Activating Factor (PAF) in Periodontal Health and Disease.

Descriptive Note : Master's thesis,

Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH

Personal Author(s) : Powell, Charles A.

PDF Url : ADA296766

Report Date : MAY 1995

Pagination or Media Count : 133

Abstract : Periodontal disease is characterized by inflammation. This inflammation protects the host against local microbial attack. However, it may not be entirely beneficial since surrounding cells, connective tissue and alveolar bone may be damaged. Clinical parameters for the detection of periodontal disease activity have received much attention over the years. Of these, gingival crevicular fluid and its contents have been an area of active research. In 1990, Rasheed and McManus presented evidence for a crevicular source of platelet-activating factor (PAF), a family of structurally-related, potent phospholipid mediators of inflammatory reactions. PAF is produced by a variety of inflammatory cells and has been isolated from inflamed human gingival tissue (Noguchi et al., 1989), and normal, mixed saliva (Cox et al., 1981; Christman and Blair 1989). Cross-sectional studies have demonstrated an increase of PAF in the mixed human saliva of periodontitis patients (Diaz et al., 1990; Braun et al., 1992; McDonnell 1994; Garito et al., 1995; Rasch et al., 1995). Therefore, it seems likely that PAF may participate in inflammatory events associated with periodontal disease. Past research concerning PAF and periodontal disease has investigated the relationship of PAF in various types of periodontal disease. No studies have attempted to define the molecular species of salivary PAF in relation to periodontal disease. Therefore, the current study was undertaken to evaluate the molecular heterogeneity of salivary PAF in periodontal health and disease.

Descriptors :   *DENTISTRY, *TEETH, *ORAL DISEASES, *ALVEOLAR BONE, TISSUES(BIOLOGY), DETECTION, HUMANS, MOLECULES, PARAMETERS, CELLS, CLINICAL MEDICINE, DISEASES, CROSS SECTIONS, HETEROGENEITY, HUMAN BODY, MIXING, PATIENTS, INFLAMMATION, POTENCY, MICROORGANISMS, CONNECTIVE TISSUE, BLOOD PLATELETS, SALIVA, PHOSPHOLIPIDS, BIODETERIORATION, GINGIVAE.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE