Accession Number : ADA296777

Title :   Use of Combination Thermal Therapy and Radiation in Breast Conserving Treatment of Extensive Intraductal Breast Cancer.

Descriptive Note : Annual rept. 29 Mar 94-28 Mar 95,

Corporate Author : NEW ENGLAND DEACONESS HOSPITAL BOSTON MA

Personal Author(s) : Svensson, Goran K. ; Burdette, Everette C.

PDF Url : ADA296777

Report Date : 28 APR 1995

Pagination or Media Count : 261

Abstract : Year O2 of this contract continues to support the development of a thermal therapy system for the treatment of breast carcinoma. The complex system instrumentation has been designed and during year O2 the fabrication and the testing of all system modules was completed. Experiments in breast phantoms and nonperfused muscle tissue demonstrate that the applicator performs according to specifications. The agreement between experiments and computer simulations is excellent, and simulations will be used for planning of individual treatments. Final systems tests will be done in June 1995 and then the system will be shipped to its clinical site. A Phase I device evaluation protocol has been developed and received IRB approval. The program has been reviewed by an external review group. Recommended revisions by this group and scientific and technical considerations have delayed the progress by approximately six months. The revisions have significantly improved the spatial resolution to allow treatment of smaller targets in the breast and by redesigning the electronics, we have improved the capability for non-invasive treatment monitoring. To compensate for this delay, we have requested a six months no-cost extension. Several new-scientific challenges have been identified and are presented in the Conclusion as areas for future research.

Descriptors :   *RADIATION, *CANCER, *MAMMARY GLANDS, TEST AND EVALUATION, THERMAL PROPERTIES, COMPUTERIZED SIMULATION, ELECTRONICS, SPATIAL DISTRIBUTION, MONITORING, SITES, RESOLUTION, CLINICAL MEDICINE, NEOPLASMS, TARGETS, COSTS, INSTRUMENTATION, THERAPY, EXTERNAL.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Radiobiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE