Accession Number : ADA297167

Title :   Mouse Models of the Neu Ligand Interaction with its Receptor in Mammary Gland Tumorigenesis and Development.

Descriptive Note : Annual rept. 1 Jun 94-31 May 95,

Corporate Author : HARVARD COLL CAMBRIDGE MA

Personal Author(s) : Leder, Philip ; Krane, Ian

PDF Url : ADA297167

Report Date : 23 JUN 1995

Pagination or Media Count : 10

Abstract : Recently, a family of stimulatory ligands for the EGF/erbB family of receptor tyrosine kinases has been described. This family includes Neu differentiation factor (NDF), heregulin (HRG), acetylcholine receptor inducing activity (ARIA), and the glial growth factors (GGFs). This family of ligands, known collectively as the neuregulins, is comprised of alternatively spliced isoforms of a common gene. Interaction of the products of this gene with heterodimers and/or homodimers of the erbB receptors leads to their auto and transphosphorylation and subsequent interaction with SH-2 proteins including phospholipase C-y (PLC-y), the p85 subunit of posphotidylinositol 3'-kinase (PI-3 K), and the GTFase activating protein of ras (ras-GAP).

Descriptors :   *CANCER, *MAMMARY GLANDS, ACTIVATION, PRODUCTION, MODELS, INTERACTIONS, PROTEINS, NEOPLASMS, LIGANDS, GENES, MICE, SENSE ORGANS, TYROSINE, PHOSPHORYLATION, PHOSPHORUS TRANSFERASES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE