Accession Number : ADA297497

Title :   Multidiscipline Approach to Understanding of Traumatic Brain Injury and the Evaluation of Drugs to Enhance Neurological Recovery after Traumatic Brain Injury.

Descriptive Note : Midterm rept. 2 Nov 92-2 May 95,

Corporate Author : LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS

Personal Author(s) : Carey, Michael E.

PDF Url : ADA297497

Report Date : JUN 1995

Pagination or Media Count : 123

Abstract : In combat, head wounds account for almost half of all single wound deaths. Since World War II neurosurgical mortality has approximated 10%, indicating no overall improvement in the lethality of brain wounds incurred in combat (1) In an attempt to alleviate this problem the US Army Medical Research and Development Command sponsored a project to develop an experimental model of brain wounding so that better treatments for brain wounded soldiers could be developed. This project was halted by animal zealots (2). The present brain injury project being conducted at Louisiana State University Medical Center is an attempt to continue the U.S. Army's efforts to develop better treatments for brain injury. In this new effort we modeled brain injury in the anesthetized rat by impacting the right sensorimotor area with a pneumatically driven piston. Owing in no small measure to the animal activists, most brain trauma work around the world is now done in the anesthetized rat using fluid percussion, weight drop or a piston impact.

Descriptors :   *BRAIN, *WOUNDS AND INJURIES, *NEUROLOGY, *TRAUMA, MEASUREMENT, PISTONS, RECOVERY, ARMY RESEARCH, IMPACT, MODELS, RATS, ARMY PERSONNEL, LETHALITY, DRUGS, MEDICAL RESEARCH, ANESTHESIA.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE