Accession Number : ADA298302

Title :   Custom Tailoring Therapy for Breast Cancer Using erbB-2.

Descriptive Note : Annual rept. 15 Dec 93-14 Dec 94,

Corporate Author : GEORGETOWN UNIV WASHINGTON DC

Personal Author(s) : Paik, Soonmyoung

PDF Url : ADA298302

Report Date : 05 JUN 1995

Pagination or Media Count : 6

Abstract : Since erbB-2 failed to be a therapeutic response variable for tamoxifen response, we have used gene trap U3lacZ to clone estrogen regulated molecules in breast cancer cells. Bcl-2 gene was identified as an estrogen inducible gene. A novel estrogen repressed gene was cloned. Their potential role as therapeutic response variable is being examined. NSABP B-11 was examined for erbB-2 expression. Statistical analysis of the B-11 is pending.

Descriptors :   *CANCER, *MAMMARY GLANDS, *ESTROGENS, HORMONES, MOLECULES, CELLS, RESPONSE, THERAPY, GENES, CLONES, STATISTICAL ANALYSIS, INFECTIOUS DISEASES, CHEMOTHERAPY.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE