Accession Number : ADA298411

Title :   The Acute Toxicity of a Mixture of the Insect Repellents Deet and AI3-3722O.

Descriptive Note : Final toxicological study, Feb-Sep 94,

Corporate Author : ARMY CENTER FOR HEALTH PROMOTION AND PREVENTIVE MEDICINE (PROVISIONAL) ABERDEE N PROVING GROUND MD

Personal Author(s) : Snodgrass, Hubert L. ; Harvey, John G.

PDF Url : ADA298411

Report Date : 01 MAY 1995

Pagination or Media Count : 34

Abstract : The purpose of the study was to determine the toxicity to animals of a mixture of the insect repellents Deet and A13-37220, and to assess its dermal effects in humans. A mixture of the insect repellents Deet and A13-37220 in 95 percent alcohol (25:25:50) did not cause primary skin irritation nor sensitization in animals, was moderately toxic by the oral route but was essentially nontoxic dermally. In humans, no skin irritation nor sensitization was produced by the repellents mix. The toxicity of the repellents mixture did not exceed the toxicities of the individual components. It is recommended that repellents mixtures containing up to 25 percent each of Deet and AI3-37220 undergo advanced entomological testing in humans. Based upon the known eye irritation potential of the individual components, it is recommended that mixtures of Deet and A13-37220 in ethyl alcohol be used with caution around the eyes and mucosa.

Descriptors :   *TOXICITY, *INSECT REPELLENTS, HUMANS, MIXTURES, ANIMALS, EYE, ETHYL RADICALS, ALCOHOLS, IRRITATION.

Subject Categories : Anatomy and Physiology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE