Accession Number : ADA298414

Title :   Transgenic Repository for Breast Cancer Research.

Descriptive Note : Annual rept. 1 Jun 94-31 May 95,

Corporate Author : JACKSON LAB BAR HARBOR ME

Personal Author(s) : Davisson, Muriel T. ; Tennent, Barbara J.

PDF Url : ADA298414

Report Date : 27 JUN 1995

Pagination or Media Count : 20

Abstract : The overall goal of this project is to develop and maintain a resource of mouse models for breast cancer research. Eleven induced mutant strains have been identified nd accepted into The Jacks on Laboratory (TJL) Induced Mutant Resource (IMR) repositor or breast cancer research models. The importation process frees mice of infectious pathogens. Embryos are cryopreserved. Correct nomenclature has been assigned, efficient breeding strategies have been developed, and typing protocols are being modified for optimal efficiency and accuracy. Strain availability is being announced in several media, including the IMR strain list accessed through TJL's WWW home page. A principal aim of this project is to transfer relevant mutations to defined genetic backgrounds. Many of these mutations were generated on mixed genetic backgrounds, which limits their usefulness for most genetic studies. After consultation with Associated Board members and other experts in the field, we have decided that transgenes arriving in mixed genetic backgrounds be transferred to the FVB inbred background. In addition, the transfer of tumor suppressor genes to backgrounds with defined susceptibility to mammary carcinogenesis may convey specific experimental advantages. The Trp53 and Rbl targeted mutations are being transferred to the BALB/cJ and C3H/OuJ inbred strains.

Descriptors :   *MEDICAL RESEARCH, *CANCER, *MAMMARY GLANDS, NEOPLASMS, ACCURACY, MUTATIONS, STRAINS(BIOLOGY), RESOURCES, GENES, MICE, EMBRYOS, GENETICS, SUPPRESSORS, JACKS(LIFTS).

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE