Accession Number : ADA298912

Title :   Reproductive Toxicity Screen of 1,3,5-Trinitrobenzene Administered in the Diet of Sprague-Dawley Rats.

Descriptive Note : Final rept. Sep 93-Jun 94,

Corporate Author : MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH

Personal Author(s) : Kinkead, E. R. ; Wolfe, R. E. ; Flemming, C. D. ; Caldwell, D. J. ; Miller, C. R.

PDF Url : ADA298912

Report Date : OCT 1994

Pagination or Media Count : 52

Abstract : Several Army installations targeted for restoration have measurable quantities of 1 ,3,5-trinitrobenzene (TNB) in the soil and ground water. As part of the process to develop environmental and health effects criteria for restoration, a modified Screening Information Data Set (SIDS) reproductive study was performed. Male and female Sprague-Dawley rats received diet containing approximately 300, 150, or 30 mg Th%B/kg diet. Mating occurred following 14 days of treatment. All dams, one-half the males, and representative pups were maintained for a total of 90 days of treatment. No mortality occurred during the study; however, a decrease in mean body weights was noted in both sexes of high-dose rats. A dose-related effect was noted in measurements of sperm function/activity. Sperm depletion and degeneration of the seminiferous tubules were noted histopathologically. Methemoglobinemia and splenic hemosiderosis were common findings in the high- and mid-dose levels of both sexes at necropsy. No adverse effects were noted in mating or fertility indices. No significant treatment-related differences were found in length of gestation, sex ratio, gestation index, or mean number of pups per litter.

Descriptors :   *TOXICITY, *DIET, *REPRODUCTION(PHYSIOLOGY), DATA BASES, MEASUREMENT, RATIOS, INFORMATION SYSTEMS, RATS, QUANTITY, HEALTH, ARMY FACILITIES, ENVIRONMENTAL IMPACT, GROUND WATER, LENGTH, ADVERSE CONDITIONS, INDEXES, MALES, MEAN, PREGNANCY, BODY WEIGHT, SEX, BLOOD DISEASES, METHEMOGLOBIN, DAMS, FERTILITY.

Subject Categories : Anatomy and Physiology
      Food, Food Service and Nutrition
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE