Accession Number : ADA299116

Title :   The Effect of Long-Term High-Carbohydrate Low-Fat Intake on Substrate Utilization and Plasma Lipoprotein Concentrations in Postmenopausal Women.

Descriptive Note : Master's thesis,

Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH

Personal Author(s) : Jatha, Gina J.

PDF Url : ADA299116

Report Date : 1995

Pagination or Media Count : 147

Abstract : The objective of this study was to determine if changes in plasma lipoprotein concentrations that occur in response to high-carbohydrate, low-fat (HCLF) intake may be associated with or result from changes in substrate utilization. By implementing three diets which replaced energy from fat with carbohydrate, stepwise, over a 16-week period, we assessed the metabolic effects of a controlled increase in carbohydrate consumption in postmenopausal women. Substrate utilization was assessed by analysis of plasma metabolites (e.g. lactate, free glycerol (FO), and free fatty acids (FFA)) as well as respiratory quotient (RQ) measurements at baseline and three different timepoints throughout the study. Fasting insulin and glucose concentrations were measured to assess insulin sensitivity. Following the increase in carbohydrate consumption, mean fasting insulin concentration decreased nearly 24% and was accompanied by a concurrent drop in fasting glucose levels. Fasting RQ measurements, plasma FFA and FG concentrations following intervention did not significantly shift from baseline concentrations. Mean total-, low-density lipoprotein- and high-density lipoprotein- cholesterol were reduced an average of 5%, 9% and 13.5% of baseline values, respectively. Both plasma triglyceride (TG) and lactate were markedly elevated relative to baseline. Plasma lactate and TG correlated significantly at two of four timepoints, with plasma TG concentrations higher in those with higher plasma lactate levels.

Descriptors :   *CHOLESTEROL, *CARBOHYDRATES, *DIET, *LIPOPROTEINS, *FATTY ACIDS, SUBSTRATES, SENSITIVITY, METABOLISM, BASE LINES, OXIDATION, HIGH DENSITY, CONCENTRATION(COMPOSITION), LEVEL(QUANTITY), RESPIRATORY SYSTEM, CONSUMPTION, LOW DENSITY, WOMEN, NUTRITION, UTILIZATION, GLUCOSE, BLOOD PLASMA, FOOD DEPRIVATION, INSULIN, GLYCEROLS, LACTATES, BLOOD PLASMA SUBSTITUTES.

Subject Categories : Food, Food Service and Nutrition
      Stress Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE