Accession Number : ADA299200

Title :   The Effect of Electroacupuncture on Cyclophosphamide-Induced Emesis in Ferrets.

Descriptive Note : Annual rept. 1 Jul 94-30 Jun 95,

Corporate Author : MARYLAND UNIV BALTIMORE

Personal Author(s) : Lao, Lixing ; Wong, Richard H.

PDF Url : ADA299200

Report Date : 27 JUL 1995

Pagination or Media Count : 27

Abstract : Nausea and vomiting are severe side-effects often associated with cancer chemotherapy and may affect treatment decisions. Cyclophosphamide is a commonly used chemotherapy agent for breast cancer and induces emesis in the ferret. In order to examine the effects of electroacupuncture (EA) on the emetogenic effect of cyclophosphamide, ferrets (1.0-1.8 kg) were placed under general anesthesia (isoflurane 5%-oxygen mixture) and were administered logarithmic doses of i.v. cyclophosphamide. A dose of 177mg/kg produced the maximal number of emetic episodes (23.3t4.O episodes) with an emetic profile consisting of two phases (first phase 18.6+3.9 episodes; second phase 4.7i1.2 episodes). For treatment, EA was given under general anesthesia followed by i.v. cyclophosphamide (177mg/kg). Various parameters were evaluated and the results indicated that EA (100Hz, 1.5V, 10 min) effectively treated the first emetic phase induced by cyclophosphamide (9.3+%1.8 episodes for first phase). EA had an effect similar to the antiemetic drug ondansetron which also treated the first phase. Preliminary studies using combination therapy of EA and metoclopramide (2.24mg/kg) showed a significant reduction in the number of emetic episodes (p=O.005).

Descriptors :   *CHEMOTHERAPY, *CANCER, *MAMMARY GLANDS, *ACUPUNCTURE, *CYCLOPHOSPHAMIDE, *EMESIS, DECISION MAKING, PROFILES, THERAPY, ANESTHESIA, EMETICS, NAUSEA.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE