Accession Number : ADA299212

Title :   Role of Metabolites in Aviation Forensic Toxicology.

Descriptive Note : Final rept.,

Corporate Author : FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROMEDICAL INST

Personal Author(s) : Chaturvedi, Arvind K. ; Canfield, Dennis V.

PDF Url : ADA299212

Report Date : AUG 1995

Pagination or Media Count : 9

Abstract : In aviation accident investigations, specimens from fatal aircraft victims are analyzed for drugs. Their presence indicates exposure to drugs and suggests possible associated medical conditions for which they might have been taken. As drugs are mostly present in therapeutic to subtherapeutic levels in aviation forensic toxicology cases, determination of parent drugs and their metabolites in multi specimens is of significance. Although chemically reactive metabolites are difficult to detect, physiologically active and inactive metabolites can be analyzed. Selective and sensitive techniques are available, but unavailability of metabolite reference standards, endogenous substance interference, and low tissue metabolite levels limit the analyses. However, the majority of primary metabolites can be effectively characterized/quantitated. Demonstrating the presence of drug (e.g., terfenadine, cocaine, THC) metabolites provides a compelling evidence for exposure to the parent drug and facilitates interpretation of results, particularly when the metabolites are active. Such analyses are not as helpful if the metabolites are also available as drugs (e.g., diazepam, temazepam, oxazepam).

Descriptors :   *AVIATION ACCIDENTS, *METABOLITES, *TOXICOLOGY, AIRCRAFT, EXPOSURE(GENERAL), SENSITIVITY, AERONAUTICS, MEDICINE, CHEMICAL REACTIONS, PHYSIOLOGICAL EFFECTS, STANDARDS, CASUALTIES, DRUGS, DETERMINATION, COCAINE, INACTIVATION, LITIGATION, DIAZEPAM, ACCIDENT INVESTIGATIONS, OXAZEPAM.

Subject Categories : Toxicology
      Military Aircraft Operations

Distribution Statement : APPROVED FOR PUBLIC RELEASE