Accession Number : ADA299278

Title :   A Comprehensive Repository of Normal and Tumor Human Breast Tissues and Cells.

Descriptive Note : Annual rept. 1 Jul 94-30 Jun 95,

Corporate Author : TEXAS UNIV AT DALLAS

Personal Author(s) : Shay, Jerry W.

PDF Url : ADA299278

Report Date : 12 JUL 1995

Pagination or Media Count : 9

Abstract : The development of breast cancer is likely to be a multi-step, progressive process with several heritable alterations accumulated during the evolution to malignancy. Since one of the major objectives of breast cancer research is to provide a means for early intervention, it is important to define the specific molecular alterations at each stage in this process. The study of such alterations is greatly aided by having not only tumor cells but also corresponding non-malignant breast cells of stromal and epithelial origin. We have established a unique repository of materials for the biologic and genetic study of breast cancer. The repository contains cryopreserved and cultured cells from tumor tissues, non-malignant epithelial and stromal cells and when available peripheral blood mononuclear cells. Patient demographic and clinical data, and family history are collected and entered onto a relational database.

Descriptors :   *CLINICAL MEDICINE, *NEOPLASMS, *MEDICAL RESEARCH, *CELLS(BIOLOGY), *CANCER, *MAMMARY GLANDS, DATA BASES, TISSUES(BIOLOGY), BIOLOGY, HUMANS, DEMOGRAPHY, EVOLUTION(GENERAL), PATIENTS, INTERVENTION, GENETICS, NUCLEI, BLOOD CELLS.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE