Accession Number : ADA299281

Title :   Biologic Effects of Her-2/Neu Gene Overexpression and Agonist and Antagonist to the Receptor in Human Breast Cancer.

Descriptive Note : Annual rept. 11 Jul 94-10 jul 95,

Corporate Author : CALIFORNIA UNIV LOS ANGELES

Personal Author(s) : Slamon, Dennis J.

PDF Url : ADA299281

Report Date : 11 JUL 1995

Pagination or Media Count : 15

Abstract : The alteration of the HER-2/neu gene has been shown to correlate with a poor prognosis in those patients whose tumors contain it. This has led to studies from our laboratory indicate that it may play a role in the pathogenesis of the disease for some patients. Given that the HERl-2/neu gene encodes a growth factor receptor found on the membrane of tumor cells and given its potential role in the pathogenesis of some human breast cancers, it is a logical target for the development of new therapeutic approaches directed at this alteration. Studies with monoclonal antibodies directed against the extra cellular domain of the receptor indicate that many may have significant growth inhibitory properties. Recently ligands have been identified which interact either directly or indirectly with the human HER-2/neu receptor, however little is known about the biologic effects of these molecules. There is some controversy as to whether the ligands mediate growth stimulatory or growth inhibitory effects or both. A greater understanding about the biologic effects of HERl-2/neu overexpression as well as the impact of agonists and antagonists to the receptor will be required to fully therapeutically exploit this gene alteration in human breast cancer. Finally, little is know about the biologic effects of other molecular alterations which may occur in combination with HER-2/neu expression.

Descriptors :   *NEOPLASMS, *MONOCLONAL ANTIBODIES, *CELLS(BIOLOGY), *RECEPTOR SITES(PHYSIOLOGY), *PHARMACOLOGICAL ANTAGONISTS, *CANCER, *MAMMARY GLANDS, PREDICTIONS, BIOLOGY, HUMANS, MOLECULES, CELLS, GROWTH(GENERAL), DISEASES, LIGANDS, THERAPY, MEMBRANES, GENES, GENETIC ENGINEERING, INHIBITION, PATHOGENESIS, SENSE ORGANS.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE