Accession Number : ADA299493

Title :   New Approaches to the Labeling of Estrogens Useful for PET.

Descriptive Note : Annual rept. 1 Jun 94-31 May 95,

Corporate Author : WASHINGTON UNIV ST LOUIS MO

Personal Author(s) : Jonson, Stephanie D.

PDF Url : ADA299493

Report Date : 29 JUN 1995

Pagination or Media Count : 11

Abstract : Progress: During this year, research has focused on understanding the chemistry of methyl hypofluorite (MeOF). MeOF is the only source of the novel electrophilic methoxylium ion species MeO+ and has been shown to react readily with C-C double bonds. Quick incorporation of C-ll with the help of MeOF will allow radiolabeling of steroids useful for positron emission tomography (PET) to disclose the location of tumor lesions and metastases with a lower dose of radiation to the patient. An estradiol derivative, 16a-methoxy estradiol, was selected as the target molecule and synthesized. Radiolabeling of the estradiol derivative with the use of C-llCH3OF was attempted, but yields were low. One of the goals for the following year is to increase this yield. Yields are being optimized by replacing the reaction solvent with radical scavenging chloroform. During the next year, the investigator will optimize radiochemical reactions for the target steroidal molecules and probe their binding affinities in tumor sites.

Descriptors :   *EMISSION, *TOMOGRAPHY, *POSITRONS, *ESTROGENS, IONS, MOLECULES, NEOPLASMS, TARGETS, RESPONSE, DOSAGE, LABELED SUBSTANCES, RADIOACTIVE ISOTOPES, LESIONS, RADIOCHEMISTRY, CHLOROFORM, STEROIDS, METASTASIS.

Subject Categories : Anatomy and Physiology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE