Accession Number : ADA299552

Title :   Oxygen Toxicity Risk Assessment.

Descriptive Note : Final rept. 1 Jan-31 Dec 87,

Corporate Author : DUKE UNIV EYE CENTER DURHAM NC

Personal Author(s) : Vann, Richard D.

PDF Url : ADA299552

Report Date : 31 MAY 1988

Pagination or Media Count : 29

Abstract : Oxygen toxicity is a consequence of breathing oxygen partial pressures greater than in atmospheric air. While oxygen itself is not toxic, the evidence indicates that toxic derivatives of oxygen are a by-product of cellular respiration. The production of toxic oxygen species increases as the tissue oxygen tension rises (Yusa et al. l987), and toxicity probably occurs due to tissue damage or interference with normal function. The toxic oxygen species produced in normoxic conditions are deactivated, but under hyperoxic conditions they accumulate. The balance between production and removal of toxic species is well-suited to mathematical modelling and statistical analysis.

Descriptors :   *TOXICITY, *OXYGEN, *RESPIRATION, *BREATHING APPARATUS, *PARTIAL PRESSURE, FUNCTIONS, REMOVAL, TISSUES(BIOLOGY), RISK, PRODUCTION, TENSION, STATISTICAL ANALYSIS, FREE RADICALS, CYTOLOGY.

Subject Categories : Anatomy and Physiology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE