Accession Number : ADA299729

Title :   Prognostic Factors in Breast Cancer.

Descriptive Note : Annual rept. 21 Nov 94-1 Aug 95,

Corporate Author : ARMED FORCES INST OF PATHOLOGY WASHINGTON DC

Personal Author(s) : Seidman, Jeffery

PDF Url : ADA299729

Report Date : 01 SEP 1995

Pagination or Media Count : 15

Abstract : The independent value of gross and histologic examination, S-phase determination, microvessel density and immunohistochemical expression of epidermal growth factor receptor (egfr), her2lneu, Ki-67 (a proliferation marker), estrogen and progesterone receptor status and p53 accumulation are being determined using a cohort of 1000 women who underwent biopay or mastectomy between 1970 and 1980 and on whom vital status has been obtained. Following accumulation of the complete data set, the relationship between survival and each of these variables will be determined using a proportional hazards model, as will the independent value of each of these prognostic indicators. In addition, the use of a backpropagation neural network model for improving prognostic statements will be explored.

Descriptors :   *CANCER, *MAMMARY GLANDS, *GROWTH(PHYSIOLOGY), *HISTOLOGICAL TECHNIQUES, DATA BASES, HAZARDS, MODELS, GROWTH(GENERAL), SURVIVAL(GENERAL), ACCUMULATION, INDICATORS, SENSE ORGANS, EPIDERMIS, PROGESTERONE, ESTROGENS.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE