Accession Number : ADA299761

Title :   Racial Differences in Breast Cancer Clinical Characteristics, Biology, and Treatment.

Descriptive Note : Annual rept. 1 Jul 94-30 Jun 95,

Corporate Author : MISSOURI UNIV-KANSAS CITY

Personal Author(s) : Moormeier, Jill

PDF Url : ADA299761

Report Date : 17 JUL 1995

Pagination or Media Count : 14

Abstract : African-American and caucasian women with newly diagnosed breast cancer were enrolled in the study. Upon enrollment, demographic data, tumor characteristics, and tumor staging data were obtained. Tumor samples were evaluated for estrogen and progesterone receptor levels, DNA ploidy, S-phase fraction, HER-2/neu expression, p53 protein accumulation, cathepsin D levels, and glutathione levels. Treatment choices, treatment received, relapse site and date, and date and cause of death were recorded in follow-up.To date, 90 women have been enrolled in the study (49 black and 41 white) and tumor samples have been analyzed in 70 women. While there have been differences between the black and white women noted in some of the above described parameters, none, as yet, reaches statistical significance.

Descriptors :   *CLINICAL MEDICINE, *DIAGNOSIS(MEDICINE), *CANCER, *MAMMARY GLANDS, *CAUCASIANS, BIOLOGY, DEMOGRAPHY, NEOPLASMS, DEOXYRIBONUCLEIC ACIDS, SAMPLING, PERSONNEL, DEATH, STAGING, SENSE ORGANS, BLACK(COLOR), GLUTATHIONE, PROGESTERONE, ESTROGENS.

Subject Categories : Medicine and Medical Research
      Personnel Management and Labor Relations

Distribution Statement : APPROVED FOR PUBLIC RELEASE