Accession Number : ADA299787
Title : A Medical Research and Evaluation Facility (MREF) and Studies Supporting the Medical Chemical Defense Program. Determination of the Minimum Effective Pyridostigmine Pretreatment Dose in Monkeys Challenged with 5 X LD50 Soman and Treated with Atropine/2-Pam.
Descriptive Note : Final rept. 22 Oct 92-31 Aug 93,
Corporate Author : BATTELLE MEMORIAL INST COLUMBUS OH
Personal Author(s) : Olson, Carl T. ; Menton, Ronald G. ; Kiser, Robyn C. ; Hayes, Timothy L. ; Matthews, M. C.
PDF Url : ADA299787
Report Date : AUG 1995
Pagination or Media Count : 180
Abstract : This task was conducted to determine the minimum dose of pyridostigmine (PYR), and the associated level of erythrocyte acetycholinesterase inhibition (AChE-I), that provides protection from 5 X 48-br GD LD50 of untreated monkeys. Monkeys were injected im with GD and treated with 0.4 mg atropine (ATR) free base and 25.7 mg pralidoxime (2-PAM) per kg BW.
Descriptors : *DEFENSE SYSTEMS, *CHEMICAL WARFARE, *MEDICAL RESEARCH, *ACETYLCHOLINESTERASE, *CHOLINESTERASE INHIBITORS, *PYRIDOSTIGMINE BROMIDE, *PYRIDINES, PEAK VALUES, DOSAGE, ERYTHROCYTES, PREVENTIVE MEDICINE, ATROPINE, MONKEYS.
Subject Categories : Biochemistry
Chemical, Biological and Radiological Warfare
Distribution Statement : APPROVED FOR PUBLIC RELEASE