Accession Number : ADA299826

Title :   Development of Ligand-Transformed Alpha-Fetoprotein for Use Against Breast Cancer in Humans.

Descriptive Note : Annual rept. 1 Jul 94-30 Jun 95,

Corporate Author : ALBANY MEDICAL COLL NY

Personal Author(s) : Bennett, James A.

PDF Url : ADA299826

Report Date : 01 JUL 1995

Pagination or Media Count : 23

Abstract : Human alpha-fetoprotein (hAFP) upon incubation with sex steroid hormones is chemically converted into an inhibitor of estrogen-dependent breast cancer growth. This document describes the progress which was made during the first year of a research grant which was designed to develop the active form of hAFP as a treatment for breast cancer and establish markers which both predict and monitor breast cancer responsiveness to this form of AFP.

Descriptors :   *PROTEINS, *CANCER, *MAMMARY GLANDS, *ESTROGENS, MAMMALS, MONITORING, HUMANS, GROWTH(GENERAL), ESCHERICHIA COLI, RESPONSE, INCUBATION, GENES, MICE, CELLS(BIOLOGY), CULTURES(BIOLOGY), RETARDATION, STEROIDS, SEX HORMONES.

Subject Categories : Anatomy and Physiology
      Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE