Accession Number : ADA299924

Title :   Mismatch Negativity (MMN) Indexes Subclinical Neurological Differences in HIV Patients during Rapid Perceptual Processing.

Descriptive Note : Final rept. Oct 92-Sep 94,

Corporate Author : NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA

Personal Author(s) : Linnville, Steven E. ; Elliott, F. S.

PDF Url : ADA299924

Report Date : FEB 1995

Pagination or Media Count : 19

Abstract : Thirteen asymptomatic HIV-infected (HIV+) and 13 healthy control (HIV-) subjects were instructed to detect 'oddball'; target tones from among a sequence of nontarget tones delivered rapidly (3 tones/sec) in one ear while ignoring a similar sequence delivered simultaneously in the opposite ear. Event-related potentials (ERPs) to all stimuli were recorded from midline scalp sites. Both groups produced ERP correlates, termed the mismatch negativity (MMN), to the oddball tones during delivery. However, the HIV+ group produced MMNs that were different in morphology to the HIV- group, suggesting that HIV may alter attentional perceptual processing. These results suggested that auditory ERPs elicited by rapid, dichotic stimulus presentations may be useful tools in monitoring subclinical effects of HIV-related neuropathology on perceptual processing.

Descriptors :   *SIGNS AND SYMPTOMS, *INFECTIOUS DISEASES, *HUMAN IMMUNODEFICIENCY VIRUSES, MONITORING, PROCESSING, CLINICAL MEDICINE, SEQUENCES, STIMULI, CELLS(BIOLOGY), HEAD(ANATOMY), PERCEPTION, SKIN(ANATOMY), CENTRAL NERVOUS SYSTEM, EAR, AUDIO TONES, PERIPHERAL NEUROPATHY.

Subject Categories : Medicine and Medical Research
      Medical Facilities, Equipment and Supplies

Distribution Statement : APPROVED FOR PUBLIC RELEASE