Accession Number : ADA299998

Title :   Proposal for Research in Quantitative Bioassay Methodology and Risk Analysis and Characterization.

Descriptive Note : Annual rept. 11 Jan 94-11 Jan 95,

Corporate Author : NAVAL POSTGRADUATE SCHOOL MONTEREY CA

Personal Author(s) : Gaver, Donald P. ; Jacobs, Patricia A.

PDF Url : ADA299998

Report Date : 20 JAN 1995

Pagination or Media Count : 188

Abstract : A summary of research conducted during the period January 12, 1994-January 12, 1995 is given. Included are results of analyses of data obtained from other investigators supported by the U.S. Army Biomedical Research and Development Command. The data sets considered included data from a pilot study conducted by Gulf Coast Research Laboratory, various data sets from a cell proliferation study using medaka, female breast cancer data, and preliminary data from a health screen study for medaka. The analysis of experimental data has focused attention on the importance of controlling experimental conditions so as to minimize unwanted sources of variability. A preliminary mathematical model to describe the production of free radical 0 that is stimulated by the introduction of an initial dose of PMA at time zero is presented. A preliminary model for the occurrence and repair of cell adducts caused by dose stimulus is also presented.

Descriptors :   *DATA BASES, *MATHEMATICAL MODELS, *QUANTITATIVE ANALYSIS, *MEDICAL RESEARCH, METHODOLOGY, EXPERIMENTAL DATA, COASTAL REGIONS, ARMY RESEARCH, RISK, CELLS, RESEARCH FACILITIES, DOSAGE, LABORATORIES, STIMULI, PILOT STUDIES, HEALTH CARE FACILITIES, CELLS(BIOLOGY), BIOMEDICINE, CANCER, BIOASSAY, MAMMARY GLANDS, MEXICO GULF.

Subject Categories : Medicine and Medical Research
      Physical Chemistry
      Computer Programming and Software

Distribution Statement : APPROVED FOR PUBLIC RELEASE