Accession Number : ADA300037

Title :   The Role of HAP Kinases in Breast Cancer.

Descriptive Note : Annual rept. 19 Aug 94-28 Aug 95,

Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s) : Kyriakis, John M.

PDF Url : ADA300037

Report Date : 29 AUG 1995

Pagination or Media Count : 14

Abstract : We have characterized a mammalian signal transduction pathway which is activated by TNF and IL-1, two cytokines which can inhibit the growth of some mammary tumor lines. This pathway uses a subfamily of the ERKs, the stress-activated protein kinases (SAPKs). SAPKs are the dominant kinases responsible for activation of the transactivation function of the transcription factor c-Jun. As such, the SAPKs relay TNF signals to the cell nucleus, thereby regulating gene expression in response to TNF.

Descriptors :   *GENES, *INHIBITION, *CANCER, *MAMMARY GLANDS, *PHOSPHORUS TRANSFERASES, MAMMALS, ENZYMES, PROTEINS, SIGNALS, TRANSDUCERS, PHOSPHORYLATION.

Subject Categories : Medicine and Medical Research
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE