Accession Number : ADA300037
Title : The Role of HAP Kinases in Breast Cancer.
Descriptive Note : Annual rept. 19 Aug 94-28 Aug 95,
Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON
Personal Author(s) : Kyriakis, John M.
PDF Url : ADA300037
Report Date : 29 AUG 1995
Pagination or Media Count : 14
Abstract : We have characterized a mammalian signal transduction pathway which is activated by TNF and IL-1, two cytokines which can inhibit the growth of some mammary tumor lines. This pathway uses a subfamily of the ERKs, the stress-activated protein kinases (SAPKs). SAPKs are the dominant kinases responsible for activation of the transactivation function of the transcription factor c-Jun. As such, the SAPKs relay TNF signals to the cell nucleus, thereby regulating gene expression in response to TNF.
Descriptors : *GENES, *INHIBITION, *CANCER, *MAMMARY GLANDS, *PHOSPHORUS TRANSFERASES, MAMMALS, ENZYMES, PROTEINS, SIGNALS, TRANSDUCERS, PHOSPHORYLATION.
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE