Accession Number : ADA300265

Title :   A Role for the NF-kB/Rel Transcription Factors in Human Breast Cancer.

Descriptive Note : Annual rept. 1 Jul 94-30 Jun 95,

Corporate Author : NORTH CAROLINA UNIV AT CHAPEL HILL

Personal Author(s) : Baldwin, Albert S.

PDF Url : ADA300265

Report Date : 28 JUL 1995

Pagination or Media Count : 25

Abstract : Human breast cancer is characterized by the inappropriate expression of growth factors, kinases and possibly certain transcription factors. Our project focuses on the potential role of a family of transcription factors, the NF-kB/Rel family, in human breast cancer. Additionally the project will analyze a role for the so-called VNTR elements in the hereditary susceptibility of women to breast cancer and on a role for estrogen in modulating cell growth of human breast cancers. We have found that approximately 35% of human breast cancers overexpress an important member of the NF-kB family (the p65 or RelA factor). Present efforts are aimed at understanding a role for this overexpression and at determining the type of tumor that is associated with this overexpression. Additionally, we have described an interesting new function of mutant/oncogenic forms of the tumor suppressor p53. Our analysis of VNTR elements has shown that bind to the important transcription factor AP-1. Future experiments are aimed at understanding a functional role for this binding to a DNA element that is associated with-human breast cancer. Additionally we have found that a constitutive form of NF-kB also binds these important elements.

Descriptors :   *CELLS(BIOLOGY), *MAMMARY GLANDS, *GROWTH(PHYSIOLOGY), *BREAST CANCER, FUNCTIONS, HUMANS, NEOPLASMS, DEOXYRIBONUCLEIC ACIDS, MODULATION, WOMEN, ESTROGENS, PHOSPHORUS TRANSFERASES.

Subject Categories : Biology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE