Accession Number : ADA300387

Title :   Cell Cycle in Normal and Malignant Breast Epithelial Cells.

Descriptive Note : Annual rept. 1 Jul 94-30 Jun 95,

Corporate Author : SCRIPPS RESEARCH INST LA JOLLA CA

Personal Author(s) : Reed, Steven I.

PDF Url : ADA300387

Report Date : 06 JUL 1995

Pagination or Media Count : 30

Abstract : Breast cancer is a disease where breast epithelial cells become refractory to appropriate growth and differentiation signals. It is likely that numerous genetic changes can contribute to malignant transformation, including mutations that alter the cell cycle regulatory machinery. We have therefore sought to characterize the function of both positive and negative cell cycle regulatory elements in normal and malignant breast epithelial cells. In particular, we have focused on cyclin E, a positive cell cycle regulatory element already implicated in some breast, malignancies and on a class of negative regulators of cyclin-dependent kinases (Cdks). Preliminary data indicate that both cyclin E and Cdk inhibitors are important in breast malignancy.

Descriptors :   *EPITHELIUM, *LIFE CYCLES, *CELLS(BIOLOGY), *CANCER, *MAMMARY GLANDS, *BREAST CANCER, CYCLES, MUTATIONS, REGULATORS, GENETICS, TRANSFORMATIONS.

Subject Categories : Biology
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE