Accession Number : ADA300394

Title :   The Role of Heparin-Binding EGF-Like Growth Factor in Breast Cancer.

Descriptive Note : Annual rept. 30 Sep 94-30 Sep 95,

Corporate Author : NATIONAL INSTITUTES OF HEALTH BETHESDA MD

Personal Author(s) : Salomon, David

PDF Url : ADA300394

Report Date : OCT 1995

Pagination or Media Count : 4

Abstract : To date no monies have been utilized from the postdoctoral research support grant that was awarded to Dr. Isabelle M. Lacaci. Dr. Lacaci just started to work in my laboratory as of September 5, 1995. She just recently received her Ph. D. degree from Georgetown University in Washington, DC. Dr. Lacaci will be assessing the EGF-related peptide, heparin binding EUF-like growth factor (HB-EGF). Dr. Lacaci will be assessing whether this cytokine is expressed in human breast cancer cells and whether its expression is regulated by hormones that are central in the development of breast cancer. In addition, Dr. Lacai will be determining whether HB-EGF is functioning as an autocrine growth factor for breast cancer cells and if so does interference in its expression perturb the growth of breast cancer cells.

Descriptors :   *HORMONES, *MAMMARY GLANDS, *GROWTH(PHYSIOLOGY), *BREAST CANCER, HUMANS, GROWTH(GENERAL), CELLS(BIOLOGY).

Subject Categories : Biology
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE