Accession Number : ADA300395

Title :   Cell-Matrix Interactions in Breast Cancer Cells.

Descriptive Note : Annual rept. 15 Aug 94-14 Aug 95,

Corporate Author : NORTHWESTERN UNIV EVANSTON IL

Personal Author(s) : Jones, Jonathan

PDF Url : ADA300395

Report Date : 17 AUG 1995

Pagination or Media Count : 48

Abstract : During the report period we have shown that breast epithelial cells attach to connective tissue via specialized matrix connectors called hemidesmosomes. The latter are lost, as are many of their components, in invasive breast tumor cells. Primary breast epithelial cells assemble hemidesmosomes in vitro. The assembly of hemidesmosomes in such cells is enhanced when they. are maintained on matrix secreted by the breast line MCFlOa. Our results emphasize the importance of matrix components in assembly of hemidesmosomes.

Descriptors :   *CELLS(BIOLOGY), *MAMMARY GLANDS, *BREAST CANCER, EPITHELIUM, NEOPLASMS, IN VITRO ANALYSIS, CONNECTIVE TISSUE, PRIMARY BATTERIES.

Subject Categories : Biology
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE