Accession Number : ADA300399

Title :   Functions of Wild-Type and Mutant Forms of p53 in Breast Cancer.

Descriptive Note : Annual rept. 1 Aug 94-31 Jul 95,

Corporate Author : COLUMBIA UNIV NEW YORK

Personal Author(s) : Chen, XinBin

PDF Url : ADA300399

Report Date : 17 AUG 1995

Pagination or Media Count : 24

Abstract : Cells induced to accumulate the p53 tumor suppressor protein have been shown to arrest in G1. This arrest is characterized by accumulation of the cyclin dependent kinase (CDK) inhibitor p2l (WAF1/CIP1) and of underphosphorylated forms of retinoblastoma protein (pRB). We show here that accumulation of the wild-type pS3 protein in either human or murine cells markedly increases expression of cyclin Dl. The induction of cyclin Dl can also be mediated by a target of p53, the p21 (WAF1/CIP1) inhibitor of cyclin-dependent kinases. The relationship between the induction of cyclin Dl and G1 arrest defines a new cellular response to p53.

Descriptors :   *MAMMARY GLANDS, *BREAST CANCER, CELLS, MUTATIONS, RESPONSE, ACCUMULATION.

Subject Categories : Biology
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE