Accession Number : ADA300589

Title :   Role of the Int-3 Oncogene in Mammary Gland Development and Tumorigenesis.

Descriptive Note : Annual rept. 15 Aug 94-14 Aug 95,

Corporate Author : COLUMBIA UNIV HEALTH SCIENCES NEW YORK

Personal Author(s) : Kitajewski, Jan ; Uyttendaele, Hendrik

PDF Url : ADA300589

Report Date : 12 SEP 1995

Pagination or Media Count : 21

Abstract : Mutational activation of the murine int-3 oncogene can contribute to mammary gland tumorigenesis. Evidence suggests that int-3 regulates the morphogenesis and functional differentiation of the mouse mammary gland. The proposed research investigates the role of int-3 proteins in the normal physiology of breast development and the biochemical properties critical for int-3 transforming activity.

Descriptors :   *TISSUES(BIOLOGY), *CELLS(BIOLOGY), *MAMMARY GLANDS, *BREAST CANCER, PRODUCTION, BIOCHEMISTRY, NEOPLASMS, SEQUENCES, LENGTH, CLONES, PHYSIOLOGY, MICE, EMBRYOS, ADULTS, AMINO ACIDS, MORPHOGENESIS.

Subject Categories : Biology
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE