Accession Number : ADA300618

Title :   The 3-D Structure of Staphylococcal Enterotoxins.

Descriptive Note : Annual rept. 1 Oct 94-30 Sep 95,

Corporate Author : VETERANS ADMINISTRATION MEDICAL CENTER PITTSBURGH PA

Personal Author(s) : Sax, M. ; Pletcher, J. ; Swaminathan, S.

PDF Url : ADA300618

Report Date : 15 OCT 1995

Pagination or Media Count : 11

Abstract : The aim of this research is to determine the crystal structures of staphylococcal enterotoxins. As was predicted from the first structure of this family of proteins to have been determined and from their sequence homology they share a common folding pattern, the SE fold. An important outcome of these studies was the identification of residues determining the V beta specifications of SEB, SEC, SEA and SEE. The crystal structure of a complex of SEB ANd 3-N-acetylneuraminlactose was solved. The trisaccharide is the head group of glysophingolipid, GM3

Descriptors :   *ENTEROTOXINS, *STAPHYLOCOCCUS, CRYSTAL STRUCTURE, SPECIFICATIONS, PROTEINS, THREE DIMENSIONAL, PATTERNS, FOLDING, CRYSTALLOGRAPHY.

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE