Accession Number : ADA300623

Title :   Evaluation of Flow Biosensor Technology in a Chronically-Instrumented Non-Human Primate Model,

Corporate Author : ARMSTRONG LAB BROOKS AFB TX AEROSPACE MEDICINE DIRECTORATE

Personal Author(s) : Koenig, S. C. ; Reister, C. ; Schraub, J. ; Muniz, G. ; Fergusan, T.

PDF Url : ADA300623

Report Date : SEP 1995

Pagination or Media Count : 3

Abstract : The Physiology Research Branch of Brooks AFB conducts both human and non-hiuman primate experiments to determine the effects of microgravity and hypergravity on the cardiovascular system and to indenti% the particular mechanisms that invoke these responses. Primary investigative research efforts in a non-human primate model require the calculation of total peripheral resistance (TPR), systemic arterial compliance (SAC), and pressure-volume loop characteristics. These calculations require beat-to-beat measurement of aortic flow. We have evaluated commercially available electromagnetic (EMF) and transit-time flow measurement techniques. In vivo and in vitro experiments demonstrated that the average error of these techniques as less than 25 percent for EMF and less than 10 percent for transit4ime.

Descriptors :   *PRIMATES, *BIOLOGICAL DETECTION, *CARDIOVASCULAR SYSTEM, *AORTA, MEASUREMENT, METHODOLOGY, VOLUME, DETECTORS, MODELS, RESISTANCE, IN VITRO ANALYSIS, PRESSURE, PHYSIOLOGY, TRANSITIONS, FLOW, IN VIVO ANALYSIS, LOOPS.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE