Accession Number : ADA300631

Title :   Measurements of Dioxin: PCB and Organochlorine Levels in Breast Adipose Tissue from Women With and Without Breast Cancer.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : CALIFORNIA PUBLIC HEALTH FOUNDATION BERKELEY

Personal Author(s) : Petreas, Myrto

PDF Url : ADA300631

Report Date : SEP 1995

Pagination or Media Count : 63

Abstract : The aim of the study is to elucidate the associations between breast cancer and the presence of organochlorine pesticides and specific PCB and PCDD/PCDF congeners in adipose tissue of women undergoing breast surgery. The target chemicals have demonstrated carcinogenic or estrogenic/anti- estrogenic potency. The study subjects are being recruited from among women undergoing open surgical biopsy, lumpectomy, or mastectomy at Stanford University Hospital. Pre-operatively, patients are interviewed regarding dietary and environmental exposures, medical and reproductive history and demographics. For the purpose of this study, cases are defined as women with definitive breast malignancies, and controls as women classified with benign histologic changes. To minimize misclassification, women with atypical hyperplasia, lobular carcinoma in situ, and any previous cancer diagnoses, as well as women taking tamoxifen are excluded. Controls will be matched to cases by five year age intervals. A questionnaire was developed and tested in a pilot phase. A total of 1 2 patients have been recruited out of the total 1 OO to be accessioned into the study. Questionnaires have been extracted and specimens are ready for chemical analysis. The study is proceeding slowly during the maternity leave of our surgeon. The pace will accelerate upon her return.

Descriptors :   *TISSUES(BIOLOGY), *MAMMARY GLANDS, *ADIPOSE TISSUE, *BREAST CANCER, ENVIRONMENTS, CHEMICALS, NEOPLASMS, TARGETS, MEDICINE, HISTORY, ORGANIC COMPOUNDS, EXTRACTION, UNIVERSITIES, PILOT STUDIES, EXPOSURE(PHYSIOLOGY), HOSPITALS, PHYSICIANS, SURGERY, WOMEN, DIET, QUESTIONNAIRES, CHEMICAL ANALYSIS, CHLORINE, PESTICIDES, CANCER, HISTOLOGY, REPRODUCTION(PHYSIOLOGY), DIOXINS, ESTROGENS.

Subject Categories : Biology
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE