Accession Number : ADA301447

Title :   Positron Emitter I124 Iododeoxyuridine as a Tracer to Follow DNA Metabolism on Scans and in Tumor Samples in Advanced Breast Cancer.

Descriptive Note : Annual rept.,

Corporate Author : SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK

Personal Author(s) : Gilewski, Teresa A.

PDF Url : ADA301447

Report Date : SEP 1995

Pagination or Media Count : 5

Abstract : The objectives of this study are: (1) to determine whether the biologic activity of locally advanced Stage III breast cancer as measured by 1241-iododeoxyuridine (IUdR) uptake on positron emission tomography (PET) scans pre and post chemotherapy can be correlated with the clinical response as determined by physical examination and conventional radiographic studies, (2) to demonstrate that incorporation of TUdR is into the DNA contained within the tumor and that it correlates with the subsequent tumor response and proliferative activity of the tumor, (3) to further assess the biologic activity of tumor sites and clinical response by using a program which fuses PET scan images on computed tomography (CT) scans, magnetic resonance imaging (MRI) or SPECT bone scans.

Descriptors :   *SCANNING, *CLINICAL MEDICINE, *DEOXYRIBONUCLEIC ACIDS, *TOMOGRAPHY, *MEDICAL EXAMINATION, *BREAST CANCER, EMISSION, BIOLOGY, SITES, NEOPLASMS, MAGNETIC RESONANCE, METABOLISM, RESPONSE, IMAGES, SAMPLING, RADIOGRAPHY, COMPUTERIZED TOMOGRAPHY, CHEMOTHERAPY, CANCER, MAMMARY GLANDS, BONES, POSITRONS.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Acoustic Detection and Detectors

Distribution Statement : APPROVED FOR PUBLIC RELEASE