Accession Number : ADA301448

Title :   PET-FDG Imaging in Metastatic Breast Cancer Treated with High Dose Chemotherapy and Stem Cell Support.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA

Personal Author(s) : Alavi, Abass

PDF Url : ADA301448

Report Date : SEP 1995

Pagination or Media Count : 10

Abstract : The study is designed to assess the effectiveness of PET-FDG imaging in patients with metastatic breast cancer who are being treated with high dose chemotherapy and stem cell rescue. This study was to include a homogeneous group of patients entered on two studies (PBT- 1 and Protocol UPCC #1192) for the treatment of breast cancer with high dose chemotherapy. We have amended our study by adding protocol UPCC #3195 as an additional source of patient accrual. The chemotherapy protocol #3195 is identical to the chemotherapy regimen used in PBT- 1, but with peripheral stem cell rescue. Until now, 5 patients have had their initial PET study before high dose chemotherapy. Two of these patients have normal or nearly normal studies, one patient has questionable right hilar uptake, one patient has diffuse bone marrow and splenic activity attributed to reactive bone marrow, but with active metastases in the dorsal spine. One patient has uptake in her right breast. These preliminary data indicate that PET can potentially predict therapeutic failures, although a larger sample and the follow-up studies will be necessary for confirmation.

Descriptors :   *DOSAGE, *BONE MARROW, *CHEMOTHERAPY, *BREAST CANCER, REACTIVITIES, DIFFUSION, TOMOGRAPHY, PATIENTS, SPLEEN, HOMOGENEITY, SPINAL COLUMN, MAMMARY GLANDS, METASTASIS.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE