Accession Number : ADA301699

Title :   Statistical Genetic Methods for Localizing Multiple Breast Cancer Genes.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : COLUMBIA UNIV NEW YORK

Personal Author(s) : Ott, Jurg

PDF Url : ADA301699

Report Date : SEP 1995

Pagination or Media Count : 8

Abstract : Genetic risks are often computed as a single number (a so-called point estimate) under the assumption that all parameters involved in the calculation of the risk are known without error. In previous work, a method was developed to allow for variability in these parameters. Technically, by the use of the maximum likelihood method, a support interval (approximate confidence interval) is constructed for the risk. This method has been extended to incorporate age-dependent penetrances in the calculation of risk support intervals. As an empirical example, the support interval for the risk is calculated for a member of a published breast-ovarian cancer kindred.

Descriptors :   *MAXIMUM LIKELIHOOD ESTIMATION, *ESTIMATES, *GENES, *STATISTICAL PROCESSES, *MAMMARY GLANDS, *BREAST CANCER, COMPUTATIONS, RISK, GENETICS, CANCER, CONFIDENCE LIMITS, INTERVALS.

Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology
      Statistics and Probability

Distribution Statement : APPROVED FOR PUBLIC RELEASE