Accession Number : ADA302073

Title :   Research Programs in Tropical and Infectious Diseases.

Descriptive Note : Final rept. 1 Dec 89-30 May 95,

Corporate Author : HENRY M JACKSON FOUNDATION ROCKVILLE MD

Personal Author(s) : Redington, Bryce ; Bryan, Joe P. ; Laughlin, Larry

PDF Url : ADA302073

Report Date : 26 JUL 1995

Pagination or Media Count : 331

Abstract : Between December 1, 1989 and May 31, 1995 a number of research projects were accomplished in Belize. The area that was most thoroughly studied was that of hepatitis. In response to reports of a number of cases of hepatitis around a banana plantation in 1990. a serosurvey of workers and their families was conducted. This revealed that up to 70% of workers had been infected with hepatitis B and almost all had been infected with hepatitis A. Later, the prevalence of hepatitis A, B. and C was investigated among the Belize Defense Force, Hepatitis B among pregnant women, health care workers, and school-aged children. A study of acute cases of jaundice was conducted over one year in the district of Stann Creek where citrus and banana plantations exists. Two hepatitis B vaccine trials were conducted among the Belize Defense Force. Other areas of investigation included malaria, leishmaniasis, diarrhea, and Chagas' Disease. A number of entomologic studies were conducted induding the use of remote sensing to predict houses with a high likelihood of malaria vectors. Work begun earlier in Pakistan was continued and resulted in the sequencing of the genome of an isolate of hepatitis E, the subsequent development of serologic assays for hepatitis E. and a PCR for Hepatitis E in feces. These tools have been used to investigate 2 outbreaks of hepatitis E in Pakistan.

Descriptors :   *INFECTIOUS DISEASES, *LEISHMANIASIS, *HEPATITIS, *DISEASE VECTORS, *TROPICAL DISEASES, PAKISTAN, SCHOOLS, REPORTS, SURVEYS, RESPONSE, DIARRHEA, REMOTE DETECTORS, PERSONNEL, RESEARCH MANAGEMENT, MALARIA, MEDICAL SERVICES, PREGNANCY, WOMEN, SEROLOGY, FECES, STREAMS, SERODIAGNOSIS, BIOASSAY, CHAGAS DISEASE.

Subject Categories : Microbiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE