Accession Number : ADA302184

Title :   The Cloning of the BRCA1 Gene.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : MONTREAL GENERAL HOSPITAL (QUEBEC) RESEARCH INST

Personal Author(s) : Narod, Steven A.

PDF Url : ADA302184

Report Date : SEP 1995

Pagination or Media Count : 118

Abstract : Dr. Narod applied techniques of linkage analysis to a panel of breast-ovarian cancer families and reduced the region of assignment of the BRCA1 gene to a 600kb interval. A physical map of this region around the 17RSDB locus was created and genes in this region were identified. In collaboration with other groups, the BRCA1 gene was cloned in late 1994. The identification of this gene has led to many important questions regarding the biology of the gene, the population genetics of BRCA1 mutations and clinical management of women who are identified to be carriers of BRCA1 mutations. Dr. Narod has studied the range of BRCA1 mutations in 60 Canadian families and 20 families from the USA. Dr. Narod has established that both genetic and non-genetic factors (reproductive history) modify the risk of cancer in carriers of BRCA1 mutations. Common mutations in particular ethnic groups have been identified. Knowledge of these ethnic associations will greatly facilitate screening efforts in the high risk population.

Descriptors :   *CLINICAL MEDICINE, *GENES, *CLONES, *GENETICS, *BREAST CANCER, HIGH RATE, RISK, MANAGEMENT, BIOLOGY, POPULATION, MUTATIONS, REGIONS, ALLOCATIONS, MAPS, ETHNIC GROUPS, GENETIC ENGINEERING, LINKAGES, WOMEN.

Subject Categories : Medicine and Medical Research
      Genetic Engineering and Molecular Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE