Accession Number : ADA302242

Title :   Biochemistry and Chemotherapy of Malaria and Leishmaniasis.

Descriptive Note : Annual rept. 2 Nov 93-1 Nov 94,

Corporate Author : MASSACHUSETTS UNIV AMHERST

Personal Author(s) : Nolan, Linda

PDF Url : ADA302242

Report Date : DEC 1994

Pagination or Media Count : 52

Abstract : Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease are either ineffective or toxic. Malaria is considered to be the most important infectious disease of humans on a world-wide scale. It is estimated that 300 million persons are infected at any one time in the world. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis and malaria. The objective of this research was to: (1) Determine the action of the antimalarial 8-aminoquinolines on Leishmania sp., (2) To identify and characterize unique DNA synthetic enzymes for the purpose of chemotherapeutic exploitation and (3) To test potential compounds sent by WRAIR and others for anti parasitic activity.

Descriptors :   *DEOXYRIBONUCLEIC ACIDS, *MALARIA, *LEISHMANIASIS, *CHEMOTHERAPY, HUMANS, TOXICITY, BIOCHEMISTRY, ENZYMES, DISEASES, SCALE, THERAPY, PARASITES, PUBLIC HEALTH, LEISHMANIA, PROTOZOA.

Subject Categories : Microbiology
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE