Accession Number : ADA302267

Title :   Breast Tumorigenesis: Interaction of Two Signaling Pathways -- TGR-Beta Versus Estrogen Receptor.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : DUKE UNIV MEDICAL CENTER DURHAM NC

Personal Author(s) : Yingling, Jonathan ; Wang, Kiao-Fan

PDF Url : ADA302267

Report Date : SEP 1995

Pagination or Media Count : 10

Abstract : The goal of this research project is to explore the role of TGF-B receptors in mammary tumorigenesis and to define the relationship between estrogen receptor and TGF-B receptor signal transduction pathways. We have pursued three approaches in addressing this question: (1) reintroduction 0 - the type II TGF-B receptor into MCF-7 cells resulting in reduced tumorigeicity, (2)characterization of the role p15 and p2i, two CdkI's,play in TG -B diated signal transduction and (3) the involvement of dwarfins in the signaling cascade downstream of the TGF-B receptors. Further analysis of - the inhibitors and dwarfins will not only contribute to our understanding breast tumorigenesis, but may reveal potential targets for therapeutic intervention.

Descriptors :   *NEOPLASMS, *MAMMARY GLANDS, *ESTROGENS, *BREAST CANCER, PRODUCTION, INTERACTIONS, TARGETS, SIGNALS, TRANSDUCERS, INHIBITORS, SENSE ORGANS.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE