Accession Number : ADA302283

Title :   The Role of Protein Kinase-C in Breast Cancer Invasion and Metastasis.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : GEORGE WASHINGTON UNIV WASHINGTON DC

Personal Author(s) : Johnson, Michael D.

PDF Url : ADA302283

Report Date : SEP 1995

Pagination or Media Count : 13

Abstract : We have determined by western blot analysis the level of expression of a number of isoforms of Protein Kinase C in a panel of breast cancer cell lines of differing invasive and metastatic potential. The cells were found to express no PKC- beta, similar levels of PKC- iota lamba and various levels of PKCs 5, E and a. Of these, PKC-alpa expression levels, particularly those of the small, active form of the enzyme, were found to correlate with invasive and metastatic behavior. These findings strengthen the hypothesis that the expression of particular isoforms is associated with invasive and metastatic behavior.

Descriptors :   *MAMMARY GLANDS, *METASTASIS, *BREAST CANCER, ENZYMES, PROTEINS, BEHAVIOR, HYPOTHESES, CANCER.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE