Accession Number : ADA302418
Title : Estrogen Responsive Breast Cancer Growth Regulation.
Descriptive Note : Annual rept. 15 Sep 94-14 Sep 95,
Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
Personal Author(s) : Sirbasku, David A.
PDF Url : ADA302418
Report Date : 05 OCT 1995
Pagination or Media Count : 21
Abstract : In this U.S. Army sponsored research program, we proposed to identify and characterize the serum factor(s) which regulated estrogen-responsive breast cancer cell growth and to conduct another study to ask if loss of serum factor(s) control was related to hormone autonomy. During the first year, we have been successful beyond our expectations. We have demonstrated that two well known plasma glycoproteins, sex hormone-binding globulin (SIlBO) and corticosteroid binding globulin (CBG) are negative regulators of steroid hormone responsive growth and that estrogens and progesterone reverse this inhibition. Furthermore, steroid hormone autonomous cells appear not to be regulated by either SHBG or CBG. Our protein chemistry data show that the SHBG we have isolated is not the common (Type I) form most often studied, but a variant that has only 30 to 40% amino acid sequence homology. The results to date suggest that breast cancer growth may be regulated by a new form of SHBG which we have designated Type II. The search for human Type II SHBG will be a major topic of this research for the next year.
Descriptors : *MILITARY MEDICINE, *CELLS(BIOLOGY), *MAMMARY GLANDS, *GROWTH(PHYSIOLOGY), *ESTROGENS, *BREAST CANCER, CONTROL, HORMONES, HUMANS, PLASMAS(PHYSICS), PROTEINS, GLYCOPROTEINS, REGULATORS, CHEMISTRY, REVERSIBLE, SELF OPERATION, BLOOD SERUM, INHIBITION, GLOBULINS, STEROIDS, CORTICOSTEROID AGENTS, PROGESTERONE.
Subject Categories : Medicine and Medical Research
Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE