Accession Number : ADA302418

Title :   Estrogen Responsive Breast Cancer Growth Regulation.

Descriptive Note : Annual rept. 15 Sep 94-14 Sep 95,

Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON

Personal Author(s) : Sirbasku, David A.

PDF Url : ADA302418

Report Date : 05 OCT 1995

Pagination or Media Count : 21

Abstract : In this U.S. Army sponsored research program, we proposed to identify and characterize the serum factor(s) which regulated estrogen-responsive breast cancer cell growth and to conduct another study to ask if loss of serum factor(s) control was related to hormone autonomy. During the first year, we have been successful beyond our expectations. We have demonstrated that two well known plasma glycoproteins, sex hormone-binding globulin (SIlBO) and corticosteroid binding globulin (CBG) are negative regulators of steroid hormone responsive growth and that estrogens and progesterone reverse this inhibition. Furthermore, steroid hormone autonomous cells appear not to be regulated by either SHBG or CBG. Our protein chemistry data show that the SHBG we have isolated is not the common (Type I) form most often studied, but a variant that has only 30 to 40% amino acid sequence homology. The results to date suggest that breast cancer growth may be regulated by a new form of SHBG which we have designated Type II. The search for human Type II SHBG will be a major topic of this research for the next year.

Descriptors :   *MILITARY MEDICINE, *CELLS(BIOLOGY), *MAMMARY GLANDS, *GROWTH(PHYSIOLOGY), *ESTROGENS, *BREAST CANCER, CONTROL, HORMONES, HUMANS, PLASMAS(PHYSICS), PROTEINS, GLYCOPROTEINS, REGULATORS, CHEMISTRY, REVERSIBLE, SELF OPERATION, BLOOD SERUM, INHIBITION, GLOBULINS, STEROIDS, CORTICOSTEROID AGENTS, PROGESTERONE.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE