Accession Number : ADA302428

Title :   The Role of Matrilysin, a Matrix Metalloproteinase, in Mammary Tumorigenesis.

Descriptive Note : Annual rept. 1 Sep 94-31 Aug 95,

Corporate Author : VANDERBILT UNIV MEDICAL CENTER NASHVILLE TN

Personal Author(s) : Matrisian, Lynn ; Rudolph, Laura

PDF Url : ADA302428

Report Date : SEP 1995

Pagination or Media Count : 16

Abstract : Due to the localization of matrix metalloproteinases (MMPs) in numerous human breast tumors, these proteins have been hypothesized to be involved in development and progression of breast cancer. We propose that matrilysin, an epithelial specific MMP, is partly responsible for the remodelling of the extracellular matrix during mammary development and tumorigenesis. To test our hypothesis, transgenic mice have been generated that overexpress matrilysin in mammary epithelial cells. Preliminary data indicates that overexpression of matrilysin induces excess branching during mammary development. Induction of mammary tumors are currently in progress. These studies will help address whether matrilysin plays a role in mammary tumorigenesis.

Descriptors :   *PROTEINS, *NEOPLASMS, *METALLOGRAPHY, *MAMMARY GLANDS, *BREAST CANCER, PRODUCTION, HUMANS, HYPOTHESES.

Subject Categories : Medicine and Medical Research
      Metallurgy and Metallography

Distribution Statement : APPROVED FOR PUBLIC RELEASE